Hypertension-The Usual Starting Dose of 50/12.5 is One Tablet Once Daily.
For Patients who do not Respond Adequately to One Tablet the Dosage may be Increased to 100/25 Once Daily.
A Patient whose Blood Pressure is not Adequately Controlled with Losartan 100 mg Monotherapy may be Switched to this Combination 100/12.5 Once Daily.
In Hypertensive Patients with Left Ventricular Hypertrophy Initial Dose is 50/12.5, if Additional Blood Pressure Reduction is Needed, 100/12.5 may be Given, Followed by 100/25 if Required. The Maximum Dose is 100/25 Once Daily.
In General, the Antihypertensive Effect is Attained within Three Weeks After Initiation of Therapy.
No Initial Dosage Adjustment of 50/12.5 is Necessary for Elderly Patients. But maximum Dose of 100/25 Once Daily Dose should not be Used as initial Therapy in Dlderly Patients.
Severe Hypertension:The Starting Dose for Initial Treatment of Severe Hypertension is One Tablet of 50/12.5 Once Daily.
For Patients who do not Respond Adequately to this Dose After 2 to 4 Weeks of Therapy, the Dosage may be Increased to 100/25 Once Daily. The Maximum Dose is One Tablet of 100/25 Once Daily.
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