Irritable Bowel Syndrome with Constipation: The Recommended Dose is 8 mcg Twice Daily Orally with Food and Water.
Dosage in Patients with Hepatic Impairment: Dosage Adjustment is not Required for Patients with Moderately Impaired Hepatic Function. For Patients with Severely Impaired Hepatic Function, the Recommended Starting Dose is 8 mcg Once Daily. If Tolerated then Dose can be Increased to 8 mcg Twice.
Chronic Idiopathic Constipation and Opioid-Induced Constipation: The Recommended Dose is 24 mcg Twice Daily Orally with Food and Water.
Dosage in Patients with Hepatic Impairment: For Patients with Moderately Impaired Hepatic Function, the Recommended Starting Dose is 16 mcg Twice Daily. For Patients with Severely Impaired Hepatic Function, the Recommended Starting Dose is 8 mcg Twice Daily.
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