Dinovo 375/20 Tablet

Rheumatoid Arthritis, Osteoarthritis and Ankylosing Spondylitis: The Dosage is One Tabletlet Twice Daily of Dinovo 375 mg Naproxen and 20 mg of Esomeprazole or 500 mg Naproxen and 20 mg of Esomeprazole. The Tabletlets are to be Swallowed Whole with Liquid. Do not Split, Chew, Crush or Dissolve the Tabletlet. Dinovo is to be Taken at Least 30 Minutes Before Meals.
Geriatric Patients: Studies Indicate that Although Total Plasma Concentration of Naproxen is Unchanged, the Unbound Plasma Fraction of Naproxen is Increased in the Elderly. Use Caution when High Doses are Required and Some Adjustment of Dosage may be Required in Elderly Patients.
Patients With Moderate to Severe Renal Impairment: Naproxen-Containing Products are not Recommended for use in Patients with Moderate to Severe or Severe Renal Impairment (Creatinine Clearance < 30 mL/min). Hepatic Insufficiency: Monitor Patients with Mild to Moderate Hepatic Impairment Closely and Consider a Possible Dose Reduction Based on the Naproxen Component of Dinovo. Dinovo is not Recommended in Patients with Severe Hepatic Impairment Because Esomeprazole Doses should not Exceed 20 mg Daily in these Patients. Pediatric Patients: The Safety and Efficacy of Dinovo in Children Younger than 18 Years have not been EsTabletlished. Dinovo is Therefore not Recommended for Use in Children.